Office 2019 includes many of the features previously published via Office 365, along with improved inking features, LaTeX support in Word, new animation features in PowerPoint including the morph and zoom features, and new formulas and charts in Excel for data analysis. Unlike other versions of Microsoft Office, Office 2019 will only get two years of extended support, which means that support for Office 2019 will end on the same day as support for Office 2016 and Windows 10, on October 14, 2025. Microsoft plans to end mainstream support for Office 2019 on October 10, 2023. Office 2019 remain same major version 16 as predecessor Office 2016, therefore it is second perpetual release of Office 16.

Some features that had previously been restricted to Office 365 subscribers are available in this release. It was unveiled on Apfor Windows 10 and Jfor macOS, and launched on September 24, 2018. It replaces Office 2016 and was replaced by Office 2021 on October 5, 2021. Microsoft Office 2019 (Second perpetual release of Office 16) is a version of Microsoft Office for both Windows and Mac.

Proofing only (11): Hausa, Igbo, isiXhosa, isiZulu, Kinyarwanda, Pashto, Romansh, Sesotho sa Leboa, Setswana, Wolof, Yoruba.

Partial (51): Afrikaans, Albanian, Amharic, Armenian, Assamese, Azerbaijani (Latin), Bangla (Bangladesh), Bangla (Bengali India), Basque (Basque), Belarusian, Bosnian (Latin), Catalan, Dari, Filipino, Galician, Georgian, Gujarati, Icelandic, Irish, Kannada, Khmer, KiSwahili, Konkani, Kyrgyz, Luxembourgish, Macedonian (Republic of Macedonia), Malayalam, Maltese, Maori, Marathi, Mongolian (Cyrillic), Nepali, Norwegian Nynorsk, Odia, Persian (Farsi), Punjabi (Gurmukhi), Quechua, Scottish Gaelic, Serbian (Cyrillic, Bosnia & Herzegovina), Serbian (Cyrillic, Serbia), Sindhi (Arabic), Sinhala, Tamil, Tatar (Cyrillic), Telugu, Turkmen (Latin), Urdu, Uyghur, Uzbek (Latin), Valencian, Welsh.

Full (40): English, Arabic, Bulgarian, Chinese (Simplified), Chinese (Traditional), Croatian, Czech, Danish, Dutch, Estonian, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Indonesian, Italian, Japanese, Kazakh, Korean, Latvian, Lithuanian, Malay (Latin), Norwegian Bokmål, Polish, Portuguese (Brazil), Portuguese (Portugal), Romanian, Russian, Serbian (Latin, Serbia), Slovak, Slovenian, Spanish, Swedish, Thai, Turkish, Ukrainian, Vietnamese.

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